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Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
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Related Experiment Video

Updated: Jan 9, 2026

Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
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Post-infection brain atrophy accelerates cognitive and molecular changes underlying dementia

Michael R Duggan1, Pyry N Sipilä2, Zhijian Yang3

  • 1Laboratory of Behavioral Neuroscience, National Institute On Aging, National Institutes of Health, Baltimore, MD, USA. dugganmr@nih.gov.

Alzheimer'S Research & Therapy
|December 5, 2025
PubMed
Summary

No abstract available in PubMed .

Keywords:
BiomarkersCognitive declineInfectionLongitudinalNeuroimaging

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