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Updated: Jan 9, 2026
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Practical Use of RNA Interference: Oral Delivery of Double-stranded RNA in Liposome Carriers for Cockroaches
Published on: May 1, 2018
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Emerging nanotechnology-enabled siRNA oral delivery platforms.
Angelea Maestas-Olguin1, Maya M Dawson2, Emily Rhoades Clark2
1Department of Chemical and Biological Engineering, University of New Mexico, Albuquerque, NM, USA.
Nanomedicine (London, England)
|December 6, 2025
Summary
Oral delivery of small interfering RNA (siRNA) using nanotechnology overcomes gastrointestinal barriers for effective gene silencing. This approach promises patient-friendly therapeutics, reducing reliance on invasive methods.
Area of Science:
- Biotechnology
- Nanomedicine
- Gene Therapy
Background:
- RNA interference (RNAi) utilizes small interfering RNA (siRNA) for sequence-specific gene silencing.
- Nanoparticle platforms have enabled clinical intravenous (IV) delivery of siRNA.
- Oral siRNA delivery faces significant gastrointestinal (GI) biological barriers.
Purpose of the Study:
- To review gastrointestinal barriers for oral siRNA delivery.
- To highlight advances in nanoparticle platforms for oral siRNA delivery.
- To explore translational aspects of oral siRNA nanomedicines.
Main Methods:
- Comprehensive review of literature on oral nanoparticle and siRNA delivery.
- Searches conducted in University of New Mexico University Libraries, Web of Science, Google Scholar, and PubMed (April-November 2025).
- Focus on nanoparticle platforms, siRNA-loaded nanoparticles, gene therapy, and nanomedicine delivery.
Main Results:
- Nanotechnology-based strategies are emerging as solutions for oral siRNA delivery.
- Recent advances show promise in overcoming GI barriers for effective gene silencing.
- Oral siRNA nanomedicines offer potential to reduce parenteral delivery and monoclonal antibody use.
Conclusions:
- Oral siRNA nanomedicines represent a promising, patient-friendly therapeutic strategy.
- This approach could significantly decrease the need for invasive treatments.
- Advances pave the way for clinically viable oral siRNA therapeutics.
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