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"Muscle quality": rethinking an imprecise term.

Jarson P Costa-Pereira1, M Cristina Gonzalez2, Alfonso J Cruz-Jentoft3

  • 1Postgraduate Program in Nutrition, Department of Nutrition, Federal University of Pernambuco, Recife, PE, Brazil.

European Geriatric Medicine
|December 6, 2025
PubMed
Summary
This summary is machine-generated.

Muscle quality lacks a clear definition, causing inconsistent research. This paper clarifies key muscle parameters and their clinical importance, suggesting standardized terms for better muscle health assessment.

Keywords:
DefinitionsMuscle architectureMuscle compositionMuscle specific-strengthTerminology

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Area of Science:

  • Biomedical Science
  • Skeletal Muscle Physiology
  • Clinical Research Terminology

Background:

  • The term "muscle quality" is broadly used in research and clinical practice.
  • A lack of a universal definition leads to inconsistent interpretations of skeletal muscle characteristics.
  • Standardized terminology is crucial for advancing research and clinical applications.

Purpose of the Study:

  • To clarify frequently assessed parameters under the umbrella of "muscle quality".
  • To provide accurate definitions for these parameters.
  • To emphasize the clinical significance of muscle health assessments.

Main Methods:

  • Literature review of studies assessing "muscle quality".
  • Analysis of functional and morphological characteristics of skeletal muscle.
  • Synthesis of definitions and clinical relevance.

Main Results:

  • "Muscle quality" encompasses diverse functional and morphological aspects.
  • Key parameters include muscle composition, architecture, and specific strength.
  • These parameters have significant clinical implications for muscle health.

Conclusions:

  • Establishing a unified framework and terminology for muscle assessment is essential.
  • Standardized terms will enhance research comparability and clinical applicability.
  • Muscle composition, architecture, and specific strength are proposed as precise descriptors.