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Updated: Jan 9, 2026

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
Published on: March 29, 2024
Lipid-Mediated Exosomal Signaling Modulates G6PD-Dependent Metabolic Remodeling in Heart Failure
Xingyue Feng1, Dongjin Wang1, Can Xu2
1Department of Cardiac Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China.
Abstract:
Mesenchymal stem-cell-derived exosomes (MSC-sEVs) represent a promising cell-free strategy for myocardial repair. Building upon the recent work by Bashir et al., we propose a complementary metabolic-lipid framework in which specific phospholipid cargoes allosterically regulate glucose-6-phosphate dehydrogenase (G6PD) to enhance pentose-phosphate-pathway (PPP) activity and sustain NADPH-dependent redox balance. Observations from LVAD-supported myocardium reveal coordinated up-regulation of G6PD-PPP enzymes during reverse remodeling, linking metabolic reprogramming to structural recovery. Lipid-mediated modulation of G6PD may therefore provide a pharmacologic bridge between exosome-based paracrine signaling and redox-driven myocardial regeneration, advancing metabolism-guided therapeutic design in heart failure.
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