The 3D Value Framework for Sustainable Access to Effective Antibiotics

Area of Science:

• Health Economics
• Pharmaceutical Policy
• Global Health

Background:

• Sustainable access to effective antibiotics is critical for addressing antimicrobial resistance (AMR) and enhancing health systems, particularly in low- and middle-income countries.
• Current pharmaceutical valuation models inadequately capture the full value of sustainable antibiotic access, leading to underestimations of societal and corporate investments.
• This undervaluation hampers efforts to address existing sustainability challenges in antibiotic supply chains.

Purpose of the Study:

• To review limitations in current pharmaceutical valuation models concerning sustainable antibiotic access.
• To propose a new framework for assessing the value of sustainable antibiotic access.
• To demonstrate the utility of the proposed framework in cost-effectiveness analysis for public decision-making.

Main Methods:

• Literature review of existing valuation models and sustainability challenges in antibiotic supply.
• Development and description of the 3D Value Framework.
• Conceptual application of the framework in cost-effectiveness analysis.

Main Results:

• Standard pharmaceutical valuation methods fail to account for the comprehensive value of sustainable antibiotic access.
• The proposed 3D Value Framework offers a straightforward and comprehensive approach to identifying valuable outcomes related to sustainable antibiotic access.
• The framework can inform public decision-making through cost-effectiveness analysis and has broader applicability.

Conclusions:

• A refined valuation approach is necessary to accurately reflect the societal benefits of sustainable antibiotic access.
• The 3D Value Framework provides a robust tool for evaluating investments in antibiotic supply security and health system strengthening.
• Implementing this framework can lead to more informed policies and investments in global antibiotic stewardship.