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Implementation of a modular digital laboratory infrastructure for SiLA 2 based devices.
Ferdinand Lange1, Tessa Habich1, Sascha Beutel1
1Institute of Technical Chemistry, Leibniz University Hannover, Callinstraße 5, Hannover 30167, Germany.
SLAS Technology
|December 6, 2025
Summary
This study presents a laboratory digitalization process using open-source tools for device control and data management. It demonstrates a SiLA-based chromatography system for protein purification and data analysis.
Area of Science:
- Laboratory automation and digitalization
- Biotechnology and bioprocessing
- Open-source scientific instrumentation
Background:
- Laboratory digitalization involves complex aspects like device control, data management, and evaluation.
- Integrating diverse laboratory equipment into a digitalized workflow presents significant challenges.
- Standardization is crucial for seamless communication between different laboratory instruments and software.
Purpose of the Study:
- To present a comprehensive laboratory digitalization process.
- To demonstrate the use of open-source software and hardware for laboratory automation.
- To showcase a practical application using a SiLA-based continuous chromatography system.
Main Methods:
- Development of a Gateway Module as a translation unit for device control protocols.
- Utilization of SiLA (Standardization in Lab Automation)-based drivers within a Docker environment.
- Implementation of a continuous chromatography system for GFP purification from cell lysate.
- Data management and storage in a dedicated system for subsequent analysis.
- Management and rollout of Gateway Module software using the mkbox-project.
Main Results:
- Successful demonstration of a SiLA-based continuous chromatography system for protein purification.
- Establishment of a functional Gateway Module for device control and communication.
- Integration of laboratory equipment with server infrastructure using open-source components.
- Secure storage and accessibility of laboratory data for analysis.
- A defined strategy for software and hardware maintenance and updates.
Conclusions:
- Laboratory digitalization is achievable using open-source solutions, enhancing flexibility and reducing costs.
- The presented SiLA-based approach facilitates seamless integration and control of laboratory automation systems.
- Effective data management and a clear update strategy are essential for sustainable laboratory digitalization.
