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Published on: August 22, 2012
Toxocara seroprevalence among suspected patients across different geographical regions in Vietnam: A retrospective
Trinh Thi Que1, Tran Van Chieu1, Trieu Thuy Anh1
1Department of Medical Biochemistry, Medlatec Laboratory Center, Medlatec Healthcare system, Hanoi, 100000, Viet Nam.
Background:
Toxocara sp. is the most common nematode in zoonotic helminth diseases worldwide. However, data on this issue remain limited in Vietnam, particularly regarding Toxocara seroprevalence in various geographical regions.
Methods:
A retrospective study was conducted on 46,284 venous blood samples from suspected toxocariasis patients across various geographical regions, which were tested at the laboratories of the Medlatec Healthcare System in Vietnam in 2023. The presence of total IgE levels and Toxocara IgG antibodies was determined using ELISA kits. Risk factors such as age, gender, geographical region, high IgE concentration (>130 IU/mL), and eosinophilia (>500 cells/μl) were evaluated.
Results:
Toxocara IgG antibodies were found in 47.63 % of patients (95 % CI: 47.18-48.09). The seroprevalence of human toxocariasis was significantly different between individuals over 60 years of age and those under 60 years. The rates of IgG antibodies against Toxocara also varied significantly between different geographical regions. Accordingly, the highest seroprevalence was observed in the North Central region (59.79 %), followed by the Northern Mountainous region (51.34 %), Red River Delta (42.79 %), South West (39.91 %), South Central (36.97 %), Central Highlands (35.78 %), and South East (33.10 %), respectively. A significant association was found between eosinophilia, high IgE concentrations, and Toxocara seropositivity (p < 0.001).
Conclusion:
The seropositivity rate to Toxocara spp. in different geographical regions in Vietnam in the year 2023 was relatively high. Further studies are needed to better understand the clinical relevance of these findings and to evaluate the feasibility and cost-effectiveness of targeted screening and control strategies.
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