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Updated: May 8, 2026
Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
Published on: April 8, 2016
Microbiological analysis of patients with inverse and plaque-type psoriasis
Pelin Ustuner1, Ayşe Nur Ceylan2
1Dermatology Department, Nisantasi University Medical Faculty, Maslak Mahallesi, Taşyoncası Sokak, No: 1 V ve No:1Y Bina Kodu: 34481742, Sarıyer/İstanbul, 34398, Türkiye. pelindogaustuner@gmail.com.
Background:
The hypothesis that the fungal and/or bacterial microbiome of the flexural folding area may be an etiopathogenetic factor for inverse psoriasis is still under discussion.
Aim:
We aimed to compare clinical features, demographic features, and microbiological data of patients with inverse and plaque psoriasis.
Materials And Methods:
Demographic and clinical data were recorded from patients with inverse psoriasis, psoriasis vulgaris, and control groups. The study took place between October 2023 and March 2024. Microbiological gel swab samples were taken randomly from either axillary or inguinal regions of lesional and non-lesional areas of the three study groups to examine the presence of pathogens, including Staphylococcus aureus and Gram-negative and diphtheroid bacteria.
Results:
The rates of positivity in Wood's lamp examination and Psoriasis Area and Severity Index scores were significantly higher in the inverse psoriasis group than the control and psoriasis vulgaris groups. The rates of diphtheroid and Gram-negative bacteria growth were higher in the lesional areas of the inverse psoriasis group than the non-lesional areas of the other groups.
Conclusion:
The results suggest that the flexural microbiota may play a role in the etiopathogenesis of inverse psoriasis, which warrants further investigation.
Insights
The flexural microbiome may contribute to inverse psoriasis development. Bacterial growth, including diphtheroids and Gram-negative bacteria, was higher in affected skin areas of inverse psoriasis patients.
Area of Science:
- Dermatology
- Microbiology
- Medical Research
Background:
- The role of the skin microbiome in inverse psoriasis etiology is debated.
- Investigating the microbial contribution to inverse psoriasis is crucial for understanding its pathogenesis.
Purpose of the Study:
- To compare clinical, demographic, and microbiological data between inverse psoriasis, plaque psoriasis (psoriasis vulgaris), and control groups.
- To identify potential microbial factors involved in inverse psoriasis.
Main Methods:
- Demographic and clinical data collection from patients with inverse psoriasis, psoriasis vulgaris, and controls.
- Microbiological analysis of swab samples from lesional and non-lesional flexural areas (axillary/inguinal).
- Detection of specific pathogens like Staphylococcus aureus, Gram-negative, and diphtheroid bacteria.
Main Results:
- Inverse psoriasis patients showed higher Wood's lamp positivity and Psoriasis Area and Severity Index scores compared to controls and psoriasis vulgaris.
- Increased growth of diphtheroid and Gram-negative bacteria was observed in lesional areas of inverse psoriasis patients.
- Specific microbial patterns were identified in the flexural skin of inverse psoriasis patients.
Conclusions:
- Findings suggest that the flexural microbiota may play a role in the etiopathogenesis of inverse psoriasis.
- Further research is warranted to elucidate the specific mechanisms by which the microbiome influences inverse psoriasis.
- Microbial analysis could offer new insights into targeted therapies for inverse psoriasis.
