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ALOX15: a key regulator in the pathogenesis and therapy of chronic rhinosinusitis with nasal polyps

Zhen Wang1, Xu Qiu1, Yuanjing Wang2

  • 1The Department of Immunology, School of Basic Medicine, Qingdao University, Qingdao, Shandong Province, China.

International Immunopharmacology
|December 7, 2025
PubMed

Insights

Arachidonate 15-lipoxygenase (ALOX15) is a key enzyme in chronic rhinosinusitis with nasal polyps (CRSwNP). Understanding ALOX15

Area of Science:

  • Biomedical Science
  • Molecular Biology
  • Immunology

Background:

  • Chronic rhinosinusitis with nasal polyps (CRSwNP) involves persistent nasal inflammation and polyp formation.
  • Many CRSwNP patients exhibit treatment resistance and disease recurrence.
  • Effective molecular targets for CRSwNP therapies are urgently needed.

Purpose of the Study:

  • To review current knowledge on arachidonate 15-lipoxygenase (ALOX15).
  • To clarify the role of ALOX15 in CRSwNP pathogenesis.
  • To highlight ALOX15 as a potential therapeutic target for CRSwNP.

Main Methods:

  • Literature review of ALOX15 in CRSwNP.
  • Analysis of molecular mechanisms involving ALOX15.
  • Synthesis of current research findings.

Main Results:

  • ALOX15 is implicated as a significant factor in CRSwNP development.
  • Specific pathways linking ALOX15 to CRSwNP pathogenesis are being elucidated.
  • ALOX15 represents a promising target for novel CRSwNP treatments.

Conclusions:

  • ALOX15 plays a critical role in the pathophysiology of CRSwNP.
  • Further research into ALOX15 mechanisms can guide therapeutic strategies.
  • Targeting ALOX15 offers potential for improved CRSwNP management.
Keywords:
15-lipoxygenase (ALOX15)Eosinophilic inflammationEpithelial cell remodelingLipid metabolism disorderMacrophage polarization

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