Embryonic and placental factors are linked with the development of autism-like behaviors in the BTBR mouse model
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View abstract on PubMed
Summary
This summary is machine-generated.Maternal environment shapes placental development, but embryonic genes drive autism-like behaviors in BTBR mice. This research highlights distinct roles of prenatal factors in neurodevelopmental disorders.
Area Of Science
- Developmental biology
- Neuroscience
- Genetics
Background
- Neurodevelopmental disorders result from complex gene-environment interactions during prenatal development.
- Understanding these interactions is crucial for identifying early risk factors and potential interventions for conditions like autism.
Purpose Of The Study
- To investigate the distinct and interactive roles of embryonic genotype and maternal environment on placental development, fetal growth, and postnatal behavior using a mouse model of autism.
- To differentiate the contributions of maternal and embryonic factors to autism-like phenotypes.
Main Methods
- Utilized the BTBR T+Itpr3tf/J (BTBR) mouse model and C57BL/6J (B6) control strain.
- Performed quantitative analyses of fetal and placental weights, morphological assessments, and reciprocal embryo transfers.
- Conducted placental transcriptomic profiling to analyze molecular pathways.
Main Results
- BTBR conceptuses exhibited strain- and stage-specific growth restriction and distinct placental morphology (enlarged labyrinth, reduced glycogen).
- Maternal strain predominantly influenced placental histology, with conceptuses developing placentas resembling their foster mothers.
- Autism-like behaviors were specific to BTBR offspring, irrespective of the maternal strain, indicating a strong embryonic genetic effect.
Conclusions
- Maternal factors primarily dictate placental architecture, while embryonic genetic determinants are linked to autism-like behaviors in the BTBR model.
- Placental metabolism pathways are significantly affected, suggesting potential for early diagnosis of neurodevelopmental risk.
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