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Updated: Jan 9, 2026

A Simple, Low-cost, and Robust System to Measure the Volume of Hydrogen Evolved by Chemical Reactions with Aqueous Solutions
Published on: August 17, 2016
Guide to liquid volume measurements: A review of methods and technologies
Nathaniel G Hentz1, John Thomas Bradshaw2
1NGH Scientific Consulting, LLC, 108 Tutbury Place, Cary, NC 27519.
Abstract:
The need to measure volume is an important component of any liquid-based assay, because the final result is often based upon the concentration of some analyte within the assay. Volume measurements can be used to determine the actual amount of sample throughout an assay. They can also be used to calibrate, routinely verify performance of, or optimize liquid classes for liquid handling platforms or other automated or manual pipetting devices. This review surveys current liquid volume measurement methods and technologies available for use in life science laboratories. Volumes considered in this review range from picoliters to a few milliliters, which are typical for life science assays. While the need for volume measurement extends across many different industries, the focus here is on applications in biopharmaceutical and clinical life science laboratories. This review evaluates key measurable attributes, including the addressable volume range, as well as the attainable precision and accuracy of the method or technology. Several important features are also considered such as the ability to measure actual samples, commercial availability, regulatory compliance, sample type, workflow integration, suitability for in-line use, and relative ease of use.
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