Related Experiment Video
Updated: Jan 9, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
The Lipoprotein(a) rs3798220 and rs10455872 polymorphisms and coronary heart disease: a meta-analysis of 55,647
Yan-Yan Li1, Hui Wang2, Yang-Yang Zhang3
1Clinical research center, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China; Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Background/Aims:
The Lipoprotein(a) (LPA) rs3798220 and rs10455872 polymorphisms have been indicated to be involved with the coronary heart disease (CHD) susceptibility. However, there are still differences between the individual studies.
Methods:
To explore the correlation of LPA gene rs3798220 and rs10455872 polymorphisms and CHD, the current meta-analysis was performed. The random or fixed effect genetic models were used to calculate the pooled odds ratios (ORs) and their corresponding 95 % confidence intervals (CI).
Results:
A significant association was found between LPA rs3798220 polymorphism and CHD under allelic (OR: 1.488), recessive (OR: 1.543), dominant (OR: 1.534), homozygous (OR: 1.544), heterozygous (OR: 1.498) and additive genetic models (OR: 1.531). There was also a significant association between LPA rs10455872 polymorphism and CHD under allelic (OR: 1.607), dominant (OR: 1.751), heterozygous (OR: 1.723) and additive genetic models (OR: 1.686).
Conclusions:
LPA rs3798220 and rs10455872 polymorphisms were significantly associated with increased CAD risk. The persons carrying C allele of LPA rs3798220 and G allele of LPA rs10455872 polymorphisms might have higher CHD risk than the T allele of rs3798220 or A allele of rs10455872 carriers.
Related Concept Videos
Coronary Artery Disease I: Introduction
Atherosclerosis III: Management
Coronary Artery Disease IV: Preventive Measures
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Single Nucleotide Polymorphisms-SNPs
Atherosclerosis I: Introduction
