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Updated: Jan 9, 2026

Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
Published on: September 29, 2011
Compatibility and comparative analysis of chronological and biological aging between the legacy 450K and the EPIC
Sven De Pourcq1, Pei-Lun Kuo2, Ann Zenobia Moore2
1Department of Experimental and Clinical Medicine, MDS Unit, University of Florence, Florence, Italy; Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Abstract:
Several epigenetic clocks based on DNA methylation arrays have been developed to evaluate biological aging. However, there is limited information on how the newer EPIC v2.0 arrays affect clock estimations, which lack probes initially present on legacy arrays such as the 450K array. Therefore, we analyzed how this absence affects epigenetic clock estimates using data from the InCHIANTI study. Although some clocks showed significant over- or underestimation due to probe loss, correlations between estimates from all 450K probes (unreduced) and shared probes between 450K and EPIC v2.0 (reduced) remained significant. AgeAcceleration estimates were least affected by missing probes.
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