Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

289
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
289
Acute Pharyngitis01:30

Acute Pharyngitis

3.7K
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
3.7K
Tonsillitis II: Management01:26

Tonsillitis II: Management

387
This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
387
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

1.1K
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical and radiographic efficacy of photobiomodulation, platelet-rich fibrin, and their combination for socket preservation: a randomized clinical trial.

BMC oral health·2026
Same author

Comparing Ultrasonically Activated Irrigation and Laser-Activated Irrigation for Postoperative Pain Reduction in Endodontics: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Journal of endodontics·2025
Same author

Optimizing Endodontic Surgery: A Systematic Review of Guided Tissue Regeneration, Grafting, and Platelet Concentrates vs. No Intervention.

Dentistry journal·2025
Same author

The XP-endo Shaper and Its Impact on Posttreatment Discomfort: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Journal of endodontics·2025
Same author

Comparative analysis of deep learning algorithms for dental caries detection and prediction from radiographic images: a comprehensive umbrella review.

PeerJ. Computer science·2024
Same author

Management Strategies for Immature Teeth with Pulp Necrosis: An Umbrella Review of Systematic Reviews.

Iranian endodontic journal·2024

Related Experiment Video

Updated: Jan 9, 2026

Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals
08:31

Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals

Published on: September 20, 2021

3.7K

Valacyclovir for Acute Apical Abscess Pain: A Randomized, Placebo-controlled, Double-blind Study.

Mohammad Sabeti1, Kyle Kitasoe2

  • 1Professor& Director, Department of Preventive and Restorative Dental Science, University of California, San Francisco, California.

Journal of Endodontics
|December 7, 2025
PubMed
Summary

Valacyclovir combined with amoxicillin significantly reduced pain in acute apical abscess patients. This antiviral therapy offers faster relief and less analgesic use compared to amoxicillin alone.

Keywords:
Acute apical abscessamoxicillinanalgesics usagepain assessmentvalacyclovir

More Related Videos

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

1.2K
Author Spotlight: Minimally Invasive Ultrasound-Guided Acupotomy in Knee Osteoarthritis Treatment
04:57

Author Spotlight: Minimally Invasive Ultrasound-Guided Acupotomy in Knee Osteoarthritis Treatment

Published on: April 26, 2024

1.1K

Related Experiment Videos

Last Updated: Jan 9, 2026

Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals
08:31

Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals

Published on: September 20, 2021

3.7K
Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

1.2K
Author Spotlight: Minimally Invasive Ultrasound-Guided Acupotomy in Knee Osteoarthritis Treatment
04:57

Author Spotlight: Minimally Invasive Ultrasound-Guided Acupotomy in Knee Osteoarthritis Treatment

Published on: April 26, 2024

1.1K

Area of Science:

  • Endodontics
  • Infectious Diseases
  • Pharmacology

Background:

  • Acute apical abscesses typically involve polymicrobial infections causing severe pain.
  • Emerging evidence suggests herpesvirus infections may play a role in abscess development.
  • This study investigates valacyclovir as an adjunct to amoxicillin for pain management.

Purpose of the Study:

  • To evaluate the efficacy of valacyclovir plus amoxicillin in managing pain associated with acute apical abscesses.
  • To compare pain reduction and analgesic use between patients receiving valacyclovir and placebo.

Main Methods:

  • A randomized, double-blind, placebo-controlled trial involving 38 patients with acute apical abscesses.
  • Patients received either amoxicillin with valacyclovir or amoxicillin with placebo for 7 days.
  • Pain levels and analgesic use were monitored daily for 6 days via phone calls.

Main Results:

  • The valacyclovir group demonstrated significantly lower mean pain scores on Days 1-3 (P < .05).
  • Faster reduction in moderate/severe pain and a higher incidence of no pain (NRS=0) were observed in the valacyclovir group.
  • Analgesic use was substantially lower in the valacyclovir group (28.6% on Day 1) compared to the placebo group (82.4%).

Conclusions:

  • Valacyclovir shows potential as an effective adjunctive treatment for acute pain relief in acute apical abscesses.
  • Early pain management can be improved by incorporating antiviral therapy.
  • Further research may confirm valacyclovir's role in endodontic pain management protocols.