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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...

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Related Experiment Video

Updated: Jan 9, 2026

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First-in-Human Procedures

Arkalgud Sampathkumar¹

¹All India Institute of Medical Sciences, Tower 12, Flat 102, CWG Village, Noida Crossing, Delhi 110092, India.

The Annals of Thoracic Surgery

|December 7, 2025

Summary

No abstract available in PubMed .

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