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Left Ventricular Dyssynchrony Assessed Using Heart Risk View Predicts Prognosis in Patients With Heart Failure　- The

Naoto Tama1, Ryohei Nomura1, Tatsuhiro Kataoka1

  • 1Department of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui.

Circulation Journal : Official Journal of the Japanese Circulation Society
|December 7, 2025
PubMed

Insights

Left ventricular (LV) dyssynchrony, measured by Heart Risk View (HRV) bandwidth, predicts heart failure (HF) prognosis. This non-invasive method aids in identifying patients at higher risk for mortality and rehospitalization.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Heart Failure Research

Background:

  • Left ventricular (LV) dyssynchrony is a known complication of heart failure (HF) progression.
  • Early identification and prognostic assessment of LV dyssynchrony remain challenging.
  • Myocardial perfusion scintigraphy offers potential for evaluating LV mechanics.

Purpose of the Study:

  • To assess the prognostic value of LV dyssynchrony using bandwidth derived from Heart Risk View (HRV) analysis.
  • To determine if HRV-derived bandwidth can predict adverse outcomes in HF patients.
  • To explore the relationship between bandwidth and other clinical parameters.

Main Methods:

  • Post hoc analysis of a prospective, single-center cohort study (n=584) of HF patients.
  • LV dyssynchrony evaluated using HRV-based bandwidth analysis of myocardial perfusion scintigraphy.
  • Composite endpoint of all-cause mortality and HF rehospitalization.

Main Results:

  • LV dyssynchrony, indicated by bandwidth (threshold 28.0°), significantly predicted HF prognosis.
  • Higher bandwidth groups showed poorer prognosis.
  • Bandwidth correlated with QRS width, LV ejection fraction (LVEF), and end-systolic volume.

Conclusions:

  • HRV-derived bandwidth is a non-invasive, objective, and reproducible measure.
  • Bandwidth analysis provides valuable prognostic information for heart failure patients.
  • This method can aid in the early identification of HF prognosis.
Abstract

Keywords:
BandwidthDyssynchronyHeart Risk ViewHeart failureLeft ventricular phase analysis

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