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Importance of CALLY Scores in Predicting Coronary Artery Bypass Grafting Outcomes

Hakkı Kursat Cetin1, Tolga Demir1

  • 1Department of Cardiovascular Surgery, SBU Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
|December 7, 2025
PubMed

Insights

Higher C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index scores predict better outcomes after coronary artery bypass grafting (CABG). Patients with high CALLY scores experienced shorter hospital stays and reduced major adverse cardiac and cerebrovascular events (MACCE).

Area of Science:

  • Cardiovascular Surgery
  • Biomarker Research
  • Surgical Outcomes

Background:

  • Coronary artery bypass grafting (CABG) outcomes can be difficult to predict.
  • Novel biomarkers are needed to assess patient risk and prognosis.

Purpose of the Study:

  • To evaluate the prognostic value of the C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index in patients undergoing CABG.
  • To determine if CALLY index scores can predict short-term and long-term outcomes after CABG.

Main Methods:

  • Patients undergoing CABG were stratified into quartiles (Q1-Q4) based on preoperative CALLY index scores.
  • Demographic, laboratory, operative, and postoperative data were collected and analyzed.
  • Outcomes including intensive care unit (ICU) stay, hospital stay, major adverse cardiac and cerebrovascular events (MACCE), and mortality were compared across quartiles.

Main Results:

  • The CALLY index showed a significant upward trend across quartiles (p = 0.001).
  • Higher CALLY index quartiles (Q3-Q4) were associated with significantly shorter ICU and hospital stays (p = 0.001).
  • MACCE rates and 2-year mortality were significantly lower in higher CALLY index quartiles (p = 0.001 and p = 0.039, respectively).
  • The CALLY index demonstrated moderate discriminative ability for predicting 2-year mortality (AUC = 0.675).

Conclusions:

  • The CALLY index is a valuable composite biomarker for predicting outcomes in CABG patients.
  • Higher preoperative CALLY index scores are associated with improved short-term recovery and reduced long-term adverse events after CABG.
  • The CALLY index can aid in risk stratification and patient management for CABG surgery.
Abstract

Keywords:
CALLY scorealbumincoronary artery bypass graftinglymphocyte

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