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Temporal Dynamics of Microlesion Effects in Subthalamic Local Field Potentials.

Naoki Tani1, Takuto Emura1, Yuki Kimoto1

  • 1Department of Neurosurgery, Osaka University Graduate School of Medicine.

Neurologia Medico-Chirurgica
|December 7, 2025
PubMed
Summary
This summary is machine-generated.

The microlesion effect after surgery for Parkinson's disease initially suppresses brain oscillations, with periodic beta power later increasing and showing distinct spatial patterns compared to aperiodic activity.

Keywords:
aperiodic componentdeep brain stimulationlocal field potentialmicrolesion effectsubthalamic nucleus

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Neurology

Background:

  • Deep brain stimulation (DBS) is a key treatment for Parkinson's disease (PD).
  • Electrode implantation causes a transient 'microlesion effect' that can alter brain activity.
  • Understanding the evolution of this microlesion effect is crucial for optimizing DBS.

Purpose of the Study:

  • To investigate the temporal evolution of subthalamic local field potentials (LFPs) post-electrode implantation in Parkinson's disease.
  • To characterize the changes in periodic and aperiodic LFP components and their spatial distribution.
  • To explore potential correlations between LFP changes and clinical outcomes.

Main Methods:

  • Analysis of resting-state LFPs from 13 Parkinson's disease patients across six postoperative periods (up to 1 year).
  • Decomposition of power spectral density into periodic and aperiodic components.
  • Nonparametric within-subject analyses and population-averaged regression for spatial evaluation.

Main Results:

  • Total LFP power and aperiodic parameters showed an inverted-U trajectory, peaking at 31-90 days.
  • Periodic beta power (13-30 Hz) increased from 1-3 months onward, remaining elevated at 6-12 months.
  • Distinct spatial topographies were observed for periodic beta (dorsal sensorimotor) and aperiodic activity (ventral).

Conclusions:

  • The microlesion effect dynamically alters LFP characteristics, with a later relative prominence of periodic beta activity.
  • Spatial dissociation between periodic and aperiodic LFP features offers insights for biomarker selection and adaptive stimulation targeting in PD.
  • While clinical improvements were noted, direct correlations with specific LFP metrics did not withstand rigorous statistical correction.