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Opioid Consumption After Laparoscopic Radical Nephrectomy in Early Postoperative Recovery Phase: A Retrospective
Karla Lilleberg1, Merja Vakkala1, Vesa Kontinen2
1Department of Anesthesiology, Research Unit of Translational Medicine, Research Group of Anesthesiology, Oulu University, Oulu University Hospital, Oulu, Finland.
Acta Anaesthesiologica Scandinavica
|December 7, 2025
Summary
Epidural analgesia after laparoscopic radical nephrectomy was linked to higher opioid use. Individualized pain management may reduce opioid consumption and side effects in these patients.
Area of Science:
- Urology
- Anesthesiology
- Pain Management
Background:
- Laparoscopic radical nephrectomy is common for kidney cancer and anomalies.
- Postoperative pain management remains a significant challenge.
- Opioids are the primary method for managing nephrectomy pain.
Purpose of the Study:
- To investigate the association between epidural analgesia and opioid consumption post-laparoscopic radical nephrectomy.
- To identify factors influencing postoperative opioid use in these patients.
Main Methods:
- Retrospective study of 226 patients undergoing elective laparoscopic radical nephrectomy.
- Recorded epidural, intravenous, and oral opioid consumption over 3 postoperative days.
- Assessed factors associated with increased opioid administration.
Main Results:
- Epidural analgesia was used in 83.2% of patients and correlated with increased opioid consumption.
- Female gender was a risk factor for higher opioid consumption.
- Higher BMI showed a negative correlation with high opioid consumption.
Conclusions:
- Epidural analgesia is associated with increased opioid consumption following laparoscopic radical nephrectomy.
- Individualized pain management protocols may decrease opioid use and adverse effects.
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