C(sp³)-H halogenation using first-row transition metal catalysts under homogeneous conditions

Area of Science:

• Catalysis
• Organic Chemistry
• Green Chemistry

Background:

• Direct functionalization of unactivated C-H bonds is a key goal in synthetic chemistry.
• Developing efficient and sustainable methods for C-H bond halogenation is crucial.

Purpose of the Study:

• To review advances in biomimetic homogeneous catalysts for C(sp3)-H halogenation.
• To highlight catalysts based on first-row transition metals for mild reaction conditions.

Main Methods:

• Focus on catalyst design strategies for C-H functionalization.
• Review of literature on first-row transition metal catalysts.

Main Results:

• First-row transition metals show significant potential in C-H halogenation.
• Biomimetic approaches enable milder and more selective reactions.

Conclusions:

• Catalyst design based on first-row transition metals is advancing C-H functionalization.
• These methods offer step-economical and atom-efficient synthetic routes.