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Related Concept Videos

Rapid Identification of Pathogens01:25

Rapid Identification of Pathogens

MALDI-TOF MS has transformed clinical microbiology by offering a rapid and reliable method for pathogen identification. The traditional approach to microbial identification typically involves time-consuming culture techniques and biochemical tests, which can delay the initiation of appropriate antimicrobial therapy. MALDI-TOF MS avoids these delays by using characteristic ribosomal protein mass patterns of microbial cells, enabling accurate species-level identification within minutes.Principle...

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An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
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Rapid Microfluidic Drug Sensitivity Testing Within 5 Days Using Minimal Clinical Tumor Samples.

Yi-Xue Chen1, Yi Zhang2,3,4, Yu-Jie Yan3

  • 1Institute of Microanalytical Systems, Department of Chemistry, Zhejiang University, Hangzhou, 310058, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|December 8, 2025
PubMed
Summary
This summary is machine-generated.

This study presents a rapid microfluidic system for personalized cancer drug screening using minimal patient samples. The innovative technology enables faster, more accurate treatment decisions for oncology patients within five days.

Keywords:
3D cell culturehigh‐throughput drug screeningmicrofluidicsorgans‐on‐a‐chippersonalized therapy

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Area of Science:

  • Biomedical Engineering
  • Oncology
  • Microfluidics

Background:

  • Current drug screening methods for clinical oncology patients are hindered by scarce samples, high consumption, and long experimental times.
  • Personalized medicine requires rapid drug sensitivity testing on patient-derived cells to guide treatment effectively.

Purpose of the Study:

  • To develop a rapid, high-throughput microfluidic system for personalized drug sensitivity testing using minimal clinical samples.
  • To enable single and combination drug screening for multiple antitumor drugs within five days.

Main Methods:

  • Fabrication of nanoliter-scale microcavity arrays using an airflow-impacting approach for ultra-smooth surfaces.
  • Rapid formation and 3D culture of tumor cell spheroids from small cell samples.
  • High-throughput drug sensitivity testing on patient-derived cells within five days.

Main Results:

  • A microfluidic system was established for rapid drug sensitivity testing, requiring minimal patient samples and avoiding cell pre-expansion.
  • The system successfully screened single and combination drug responses in primary samples from 21 breast cancer patients.
  • Tumor heterogeneity was preserved, and responses to chemotherapy and endocrine drugs were quantified.

Conclusions:

  • The developed microfluidic system offers a rapid and efficient platform for personalized drug screening in oncology.
  • This technology can significantly improve treatment guidance for cancer patients by providing timely drug response data.
  • The system's ability to preserve tumor heterogeneity is crucial for accurate personalized treatment strategies.