Research Advances in the Efficacy and Mechanism of Guipi Capsule in Reducing Insomnia

Insomnia is a common clinical disorder characterized by difficulty falling asleep or maintaining sleep with daytime irritability or fatigue. The annual prevalence of insomnia symptoms in the global adult population is 35-50% and the prevalence of insomnia disorders is 12-20%. Most patients with insomnia cost a lot but fail to receive effective treatment. First-line treatments for insomnia include cognitive-behavioral therapy (CBT-I) and medication, but they both have limitations such as expensive and serious side effects. Traditional Chinese herbal remedies, such as the Guipi capsule, are selected as an alternative strategy of treatment because of more convenient, affordable, and fewer side-effects. Here, we review the potential pathogenesis of insomnia, the pharmacological ingredients of the Guipi capsule, and its effects and mechanisms in treating insomnia.