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ADAMTS-8 and kallikrein-related peptidases 10 and 5 proteases also have a tumor suppression role

Eva G Palacios Serrato1, Karen H Medina-Abreu1, Enrique Oropeza-Martínez1

  • 1Posgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, Mexico City 03100, Mexico.

World Journal of Clinical Oncology
|December 8, 2025
PubMed

Insights

Certain proteases, like ADAM metallopeptidase with thrombospondin type 1 motif 8 and kallikrein-related peptidases 5 and 10, act as tumor suppressors. Their antitumoral effects suggest potential as cancer biomarkers and therapeutic targets.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Proteases are crucial for cellular homeostasis, regulating extracellular and intracellular processes.
  • Deregulation of protease activity is linked to various pathologies, notably cancer, where they can promote tumor growth.
  • Some proteases, including ADAM metallopeptidase with thrombospondin type 1 motif 8 (ADAMTS8) and kallikrein-related peptidases (KLKs) 5 and 10, exhibit tumor-suppressive roles.

Purpose of the Study:

  • To review the known antitumoral effects of ADAMTS8, KLK5, and KLK10.
  • To explore the potential of these proteases as cancer biomarkers.
  • To discuss their therapeutic potential in oncology.

Main Methods:

  • Literature review of studies investigating ADAMTS8, KLK5, and KLK10 in cancer.
  • Analysis of reported antitumoral mechanisms and contexts.
  • Synthesis of findings regarding biomarker and therapeutic applications.

Main Results:

  • ADAMTS8, KLK5, and KLK10 demonstrate tumor-suppressive activities in specific cancer types.
  • These proteases influence extracellular matrix degradation, cell adhesion, and growth factor signaling.
  • Evidence suggests their potential utility in cancer diagnostics and treatment strategies.

Conclusions:

  • ADAMTS8, KLK5, and KLK10 represent a class of proteases with significant antitumoral functions.
  • Their roles highlight the complex involvement of proteases in cancer, with both pro- and anti-tumorigenic potential.
  • These findings support further investigation into ADAMTS8, KLK5, and KLK10 as novel cancer biomarkers and therapeutic targets.
Keywords:
ADAM metallopeptidase with thrombospondin type 1 motif 8Kallikrein-related peptidases 10Kallikrein-related peptidases 5KallikreinsProteasesTumor suppressor

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