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T-cell Response Induced by the BNT162b2 COVID-19 Vaccine in Children

Isabel Vogler1, Stephanie Renken1, Rolf Hilker1

  • 1BioNTech SE, Mainz, Germany.

Open Forum Infectious Diseases
|December 8, 2025
PubMed

Insights

The BNT162b2 vaccine is safe and effective for children aged 5-11 years. Vaccination in 10-11-year-olds generates protective neutralizing antibodies and T-cell responses.

Area of Science:

  • Pediatric Infectious Diseases
  • Vaccinology
  • Immunology

Background:

  • The BNT162b2 mRNA vaccine has shown tolerability and efficacy in younger age groups.
  • Previous trials established the safety and effectiveness of a two-dose regimen followed by a booster for children aged 5-11 years.

Purpose of the Study:

  • To assess the immunogenicity of the BNT162b2 vaccine in 10-11-year-old children.
  • To evaluate the induction of neutralizing antibodies and T-cell responses post-vaccination.

Main Methods:

  • Analysis of data from Phase 1 and Phase 2/3 trials (NCT04816643).
  • Measurement of neutralizing antibody titers and T-cell responses in participants aged 10-11 years.

Main Results:

  • Vaccination with BNT162b2 induced significant levels of neutralizing antibodies in 10-11-year-old participants.
  • The vaccine also elicited a robust T-cell mediated immune response.

Conclusions:

  • The BNT162b2 vaccine is immunogenic in 10-11-year-old children.
  • These findings support the vaccine's role in protecting this age group against coronavirus disease 2019 (COVID-19).

Keywords:
COVID-19SARS-CoV-2T-cell responseschildrenvaccine

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