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Cardiac Involvement in Systemic Lupus Erythematosus.
Vrinda Vyas1, Vandita Vyas2, Akash Sharma3,4
1Cardiology, ECU Health, Tarboro, NC 27886, USA.
Reviews in Cardiovascular Medicine
|December 8, 2025
Summary
Systemic lupus erythematosus (SLE) is an autoimmune disease causing organ damage. This review details cardiac issues in SLE patients, covering causes, symptoms, and treatments to reduce heart complications.
Area of Science:
- Rheumatology
- Cardiology
- Immunology
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by autoantibodies and immune complex deposition.
- Cardiovascular complications are a major cause of morbidity and mortality in SLE patients.
- Understanding cardiac involvement is crucial for managing SLE.
Purpose of the Study:
- To provide a comprehensive review of cardiac manifestations in SLE.
- To discuss the epidemiology, risk factors, pathogenesis, clinical features, diagnosis, and treatment of cardiac SLE.
- To explore emerging therapies and future research for mitigating cardiac complications.
Main Methods:
- Literature review of existing studies on SLE and cardiovascular disease.
- Analysis of the role of autoantibodies, endothelial dysfunction, and immune complex-mediated injury.
- Synthesis of current knowledge on diagnosis and treatment strategies.
Main Results:
- SLE affects multiple organs, with significant cardiovascular implications.
- Key pathogenic mechanisms include autoantibodies, endothelial dysfunction, and immune complex deposition.
- A range of clinical features, diagnostic tools, and treatment options are available.
Conclusions:
- Cardiac complications are a critical concern in SLE management.
- Further research into emerging therapies is needed to improve patient outcomes.
- Integrated approaches are essential for mitigating cardiovascular risks in SLE.
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