Related Experiment Video
Updated: Jan 9, 2026
13:07
Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
4.3K
Optical Coherence Tomography in Acute Coronary Syndromes
Andreas Synetos1,2, Leonidas Koliastasis1,3, Nikolaos Ktenopoulos1
1First Department of Cardiology, School of Medicine, National and Kapodistrian University of Athens, Hippokration General Hospital of Athens, 11527 Athens, Greece.
Reviews in Cardiovascular Medicine
|December 8, 2025
Summary
Optical coherence tomography (OCT) offers detailed coronary artery imaging, improving diagnosis and treatment for acute coronary syndromes (ACS). This intravascular imaging technique enhances procedural guidance and patient outcomes compared to traditional angiography.
Area of Science:
- Cardiovascular Imaging
- Interventional Cardiology
Background:
- Coronary angiography provides limited 2D views, hindering assessment of vessel wall pathology.
- Intravascular imaging modalities like IVUS and OCT offer high-resolution cross-sectional views, complementing angiography.
Purpose of the Study:
- To review the evolving role of Optical Coherence Tomography (OCT) in managing Acute Coronary Syndromes (ACS).
- To highlight the impact of OCT on improving patient outcomes in ACS.
Main Methods:
- Review of evidence from registries, randomized controlled trials, and meta-analyses.
- Discussion of advancements in intravascular imaging technologies (e.g., NIRS, VH-IVUS).
Main Results:
- Intravascular imaging techniques provide detailed pathology evaluation and procedural guidance.
- OCT offers critical diagnostic insights for ACS, enhancing treatment accuracy.
- Evidence supports intravascular imaging-guided percutaneous coronary interventions for improved outcomes.
Conclusions:
- OCT is crucial for accurate diagnosis and optimal treatment strategies in ACS.
- The use of OCT in ACS management leads to favorable patient outcomes.
- Intravascular imaging significantly enhances percutaneous coronary interventions.
Related Concept Videos
01:30Acute Coronary Syndrome III: Diagnostic Studies
199
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
199
01:30Acute Coronary Syndrome I: Introduction
736
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
736
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
325
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
325
01:26Acute Coronary Syndrome V: Nursing Management
249
Nursing Assessment:Nursing management of acute coronary syndrome (ACS) involves taking the patient's history, focusing on primary complaints such as chest pain, dyspnea, and excessive sweating (diaphoresis), as well as other symptoms like back or jaw pain, nausea, vomiting, palpitations, dizziness, and fatigue. The nurse also reviews the patient's history of cardiac events, risk factors such as hypertension, diabetes, smoking, family history, and current medications.In the objective assessment,...
249
01:28Imaging Studies for Cardiovascular System V: CT
261
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
261
01:27Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
440
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
440