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β-Glucan Chitosan Particle Provides Cross-Protection Against Multi-Drug- Resistant Candida auris.

Shakti Singh¹, Ashley Barbarino¹, Eman G Youssef¹

¹The Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Angeles (UCLA) Medical Center.

Research Square

|December 8, 2025

Summary

A novel β-glucan chitosan particle (GCP) vaccine candidate shows promise against multidrug-resistant Candida auris. GCP vaccination protected mice from lethal C. auris infection by eliciting protective immune responses.

Keywords:

Candida auris candidiasis cross-reactive vaccine β-glucan particle

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Area of Science:

Mycology
Immunology
Infectious Diseases

Background:

Candida auris is a multidrug-resistant fungal pathogen causing life-threatening infections, particularly in healthcare settings.
High mortality rates and resistance to antifungals necessitate alternative therapeutic strategies.
C. auris cell walls contain β-glucan, a targetable component similar to other yeasts.

Purpose of the Study:

To evaluate β-glucan chitosan particles (GCP) as a vaccine candidate against Candida auris.
To assess the humoral and cellular immune responses induced by GCP vaccination.
To determine the protective efficacy of GCP against disseminated C. auris infection in a murine model.

Main Methods:

GCP were formulated and tested for their ability to induce immune responses.
Humoral (IgG antibody) and cellular (Th1/Th2/Th17) immune responses were evaluated.
Vaccinated mice were challenged with C. auris, and survival rates, fungal burden, and organ damage were assessed.

Main Results:

GCP vaccination induced robust IgG antibody and Th1/Th2/Th17 immune responses.
Anti-GCP antibodies cross-reacted with C. auris cell walls across major clades.
GCP-vaccinated mice showed significantly improved survival (40% vs. 0%) and reduced fungal burden compared to placebo.

Conclusions:

GCP serves as a promising vaccine candidate against multidrug-resistant Candida auris.
Protection appears to be mediated by both antibody and T-cell activation.
This study represents a significant advancement in developing an effective vaccine strategy for C. auris infections.