Related Experiment Video

Updated: Jan 9, 2026

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Janus kinase/signal transducer and activator of transcription pathway in schizophrenia (Review)

Emmanouil Rizos1, Christos Theleritis1, James N Tsoporis2

  • 1Second Department of Psychiatry, Attikon University General Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.

Biomedical Reports
|December 8, 2025
PubMed

Insights

This review explores the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Psychiatry

Background:

  • Schizophrenia is a complex mental disorder impacting cognition, emotion, and behavior.
  • The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway is frequently dysregulated in schizophrenia.
  • Inflammation, driven by signaling pathway dysregulation, is crucial in schizophrenia's onset and progression.

Purpose of the Study:

  • To provide an overview of dysregulated signaling in schizophrenia.
  • To focus on the role of the JAK/STAT pathway in schizophrenia.
  • To highlight the potential of JAK/STAT research for therapeutic strategies.

Main Methods:

  • Literature review of studies on signaling pathways in schizophrenia.
  • Focus on research detailing JAK/STAT pathway involvement.
  • Analysis of the link between JAK/STAT dysregulation and schizophrenia pathophysiology.

Main Results:

  • The JAK/STAT pathway is implicated in key processes like neurogenesis, gliogenesis, synaptic plasticity, and microglia activation in schizophrenia.
  • Dysregulation of this pathway contributes to inflammation, a critical factor in the disorder.
  • Evidence suggests a multifaceted role for JAK/STAT signaling in the complex mechanisms of schizophrenia.

Conclusions:

  • The JAK/STAT pathway is a significant player in schizophrenia pathogenesis.
  • Understanding JAK/STAT dysregulation offers insights into schizophrenia's inflammatory and cellular processes.
  • Targeting JAK/STAT components may lead to novel therapeutic interventions for schizophrenia.
Keywords:
JAK/STAT pathwaySTATsschizophreniasignaling

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