A Survey Evaluating the Relationship Between the Perceived Side Effects of Hormonal Contraception and Physical...

Nearly all females use some form of contraception in their lifetimes, making hormonal contraception (HC) a prevalent hormonal landscape. The purpose of this survey was to characterize the prevalence of HC use and the associated perceived side effects in active U.S. adult females.

Six hundred seventy active adult females between ages 18 and 52 years living in the United States (age = 30.7 ± 8.1 years; body mass index = 25.4 ± 5.5 kg/m²) completed an online questionnaire based on previously validated assessments to characterize menstrual cycle, prevalence of HC use, perceived side effects, and physical activity. Physical activity was reported in minutes over 7 days and converted into metabolic equivalent-minutes per week. Data are reported as descriptive statistics and proportions; Pearson's chi-squared analyses were used to examine the relationships between categorical variables.

Overall, 65.2% of females reported using HC. Combined oral contraceptives were most commonly used (48.3%), followed by intrauterine devices (40.7%). Compared with non-HC users, HC users reported a significantly lower occurrence of premenstrual syndrome (65.7% vs. 54.0%, respectively; p = .004). Compared with the prevalence of perceived negative side effects, HC users reported a higher prevalence of perceived positive side effects. Progestin-only HC users reported significantly more perceived negative side effects than combination HC users (58.2% vs. 48.5%, respectively; p = .042). The physical activity level did not appear to influence perceived side effects.

HC use in females remains very high. HC users reported a higher number of perceived positive side effects compared with perceived negative side effects; the type of HC method may impact the perceived side effects.