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Updated: Jan 9, 2026

Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart
Published on: April 15, 2020
Role of SOX9 in cardiovascular diseases: Evidence today
Angat Naresh Chadha1,2, Han Cheng1,3, Jing Yang4
1Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China.
Abstract:
SRY-related high-mobility group box 9 (SOX9) is an indispensable transcription factor that regulates multiple developmental pathways related to stem cell differentiation and progenitor cell development. Several studies have investigated the role of SOX9 in chondrogenesis and oncogenesis. Significant research exists describing the role of SOX9 in embryological development of the cardiovascular system. However, there is limited research exploring the roles of SOX9 in development of cardiovascular diseases. In this review we highlight and review the biology and contributions of SOX9 in embryologic cardiac development and shed some light on its participation in the development of myocardial fibrosis, which in turn leads to a wide variety of adverse cardiac outcomes.
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