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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Related Experiment Video

Updated: Jan 9, 2026

Zebrafish Keratocyte Explants to Study Collective Cell Migration and Reepithelialization in Cutaneous Wound Healing
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Acellular Fish Skin for Deep Dermal Traumatic Wounds Management: A Case Report.

Esmaeil Biazar1, Saeed Heidari-Keshel2,3, Mahdiye Sadat Rezaee3

  • 1Tissue Engineering Group, Department of Biomedical Engineering To.C., Islamic Azad University Tonekabon Iran.

Clinical Case Reports
|December 8, 2025
PubMed
Summary
This summary is machine-generated.

A novel wound dressing combining platelet-rich fibrin (PRF), plasma-rich growth factor (PRGF), and acellular fish skin (AFS) significantly accelerated healing and improved outcomes for deep dermal wounds. This combination offers a promising alternative to traditional treatments, enhancing skin regeneration and reducing scarring.

Keywords:
acellular fish skinplatelet‐rich fibrintransplantationwound healingxenograft

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Wound Healing Research

Background:

  • Extracellular matrix (ECM)-based wound dressings show potential for tissue repair.
  • Bioactive components in ECM materials can accelerate healing and regeneration.
  • Minimizing inflammation and promoting scar-free healing are key goals in wound management.

Purpose of the Study:

  • To evaluate the efficacy of a novel wound dressing combining platelet-rich fibrin (PRF), plasma-rich growth factor (PRGF), and acellular fish skin (AFS) grafts.
  • To assess healing, functional, and aesthetic outcomes in deep dermal traumatic wounds over a one-year follow-up.
  • To compare the novel treatment with conventional wound care methods.

Main Methods:

  • Case report involving a 34-year-old woman with deep dermal traumatic wounds.
  • Treatment involved a combination of PRF gel, PRGF gel, and AFS grafts.
  • Objective and subjective assessments were conducted over a 12-month period.

Main Results:

  • Wounds treated with AFS demonstrated significantly faster healing rates.
  • Improved skin water retention, reduced pain, and enhanced elasticity, thickness, and pigmentation were observed.
  • Superior functional and aesthetic outcomes were achieved compared to conventional treatments.

Conclusions:

  • The synergistic application of PRF, PRGF, and AFS grafts is a promising alternative for deep dermal wound management.
  • This combination promotes accelerated healing and superior long-term outcomes.
  • Decellularized fish skin grafts, combined with growth factors, offer significant advantages over split-thickness skin grafts.