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Related Experiment Video

Updated: Jan 9, 2026

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
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Lower Extremity Flow Quantification Using Dynamic 82Rb PET: a Preclinical Investigation.

Liang Guo1, Stephanie L Thorn2, Pedro Gil de Rubio Cruz2

  • 1Department of Biomedical Engineering, Yale University, New Haven, CT 06520 USA.

IEEE Transactions on Radiation and Plasma Medical Sciences
|December 8, 2025
PubMed
Summary

Dynamic Rubidium-82 PET imaging accurately assesses lower extremity skeletal muscle blood flow in a porcine hindlimb ischemia model. This technique aids in managing peripheral arterial disease (PAD) and critical limb ischemia.

Keywords:
Peripheral arterial diseasedelay timedispersiondynamic PET imagingkinetic modeling

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Area of Science:

  • Cardiovascular Imaging
  • Nuclear Medicine
  • Physiology

Background:

  • Peripheral arterial disease (PAD) with critical limb ischemia necessitates accurate assessment of lower extremity blood flow.
  • Dynamic PET imaging offers a potential method for evaluating regional perfusion.

Purpose of the Study:

  • To investigate dynamic 82Rb PET imaging with kinetic modeling for assessing skeletal muscle flow in a porcine hindlimb ischemia model.
  • To evaluate the impact of input function corrections and single-injection protocols on flow quantification.

Main Methods:

  • Utilized dynamic 82Rb PET imaging in a porcine model with acute unilateral hindlimb ischemia.
  • Employed a three-parameter one-tissue compartment with spillover (1T-spillover) model for skeletal muscle flow estimation.
  • Assessed two protocols: sequential injections for input function and flow, and a single injection with shuttling for short axial field of view (SAFOV) scanners.

Main Results:

  • Skeletal muscle flow estimates ranged from 0.012 to 0.077 cm3/min/cm3 and were significantly reduced in ischemic limbs (p < 0.05).
  • Delay and dispersion corrections of the left ventricle image-derived input function (LV-IDIF) improved model fitting (AIC) and physiological consistency.
  • Accurate flow quantification was more challenging with the single injection and shuttling protocol.

Conclusions:

  • Dynamic 82Rb PET imaging with kinetic modeling is feasible for quantifying skeletal muscle flow in a hindlimb ischemia model.
  • Input function corrections are crucial for accurate flow estimation.
  • Further optimization of data acquisition protocols, especially for SAFOV scanners, is needed for clinical translation.