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Updated: Jan 9, 2026

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Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo
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Full-Spectrum Pachychoroid Manifestation in One Eye: A Case Report
Jeffrey DeWitt Warner1, Anusha Tuli2, Daniel D Zhang3
1Department of Ophthalmology, UNMC Truhlsen Eye Institute, Omaha, NE, USA.
Case Reports in Ophthalmology
|December 8, 2025
Summary
This rare case study presents all four stages of the pachychoroid spectrum—pachychoroid pigment epitheliopathy (PPE), central serous chorioretinopathy (CSC), pachychoroid neovasculopathy (PNV), and polypoidal choroidal vasculopathy (PCV)—simultaneously in one eye.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Choroidal Disorders
Background:
- The pachychoroid spectrum encompasses chorioretinal disorders including PPE, PNV, PCV, and CSC.
- These conditions are believed to represent sequential stages of a single disease process.
- The spectrum ranges from early RPE changes to advanced neovascularization and aneurysmal dilation.
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