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A Comparative Analysis Between Soft Tissue Manipulation and Pharmacotherapy in TMJ Myofascial Dysfunction Management:
Peeyoosha Gurudut1, Zameera Naik2, Krupa Metgud1
1Department of Orthopedic Physiotherapy, KLE Institute of Physiotherapy, Belagavi, Karnataka, India.
International Journal of Therapeutic Massage & Bodywork
|December 8, 2025
Summary
Soft tissue manipulation effectively treats temporomandibular joint (TMJ) myofascial pain dysfunction syndrome (MPDS), improving pain and mouth opening. Pharmacotherapy showed limited benefits, primarily pain reduction without enhancing jaw mobility.
Area of Science:
- Musculoskeletal disorders
- Pain management
- Physical therapy
Background:
- Myofascial pain dysfunction syndrome (MPDS) is a common temporomandibular joint (TMJ) disorder causing pain and limited mouth opening.
- Pharmacotherapy is a common treatment but has side effects.
- Soft tissue manipulation offers a safer alternative, but comparative data is limited.
Purpose of the Study:
- To compare the effectiveness of soft tissue manipulation versus pharmacotherapy for MPDS affecting the TMJ.
Main Methods:
- A single-blinded randomized controlled trial was conducted in a tertiary care hospital.
- 34 participants were randomized into soft tissue manipulation (massage, myofascial release) or pharmacotherapy (muscle relaxants, analgesics) groups.
- Outcomes included pain scales (NPRS, CGPV 2.0), maximum mouth opening (MMO), and TMJ Disability Index (TMI).
Main Results:
- Both groups showed significant improvements in pain, CGPV 2.0, MMO, and TMI (p=0.001).
- Intergroup comparison revealed no significant difference in pain reduction (p=0.066).
- Soft tissue manipulation was superior in improving CGPV 2.0, MMO, and TMI (p=0.001).
Conclusions:
- Soft tissue manipulation is more effective than pharmacotherapy for MPDS of the TMJ.
- It significantly alleviates pain, improves mouth opening, and reduces disability.
- Pharmacotherapy primarily offers pain relief without improving jaw mobility.

