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QingXia HuaYu Formula Alleviates Severe Acute Pancreatitis-Associated Intestinal Injury by Modulating Group 3 Innate
Yuyang Liu1,2, Yishuang Tang3, Yue Wu1
1Department of Gastroenterology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Gastroenterology Research and Practice
|December 8, 2025
Summary
The QingXia HuaYu (QXHY) formula helps severe acute pancreatitis (SAP) by improving intestinal injury. QXHY enhances innate lymphoid cells (ILC3s) to reduce inflammation and restore gut health.
Area of Science:
- Gastroenterology
- Immunology
- Traditional Chinese Medicine
Background:
- Severe acute pancreatitis (SAP) is a critical condition causing systemic inflammation and intestinal injury.
- Innate lymphoid cells (ILCs) are implicated in the link between SAP and gut damage.
- The therapeutic mechanisms of Traditional Chinese Medicine (TCM), like the QingXia HuaYu (QXHY) formula, in SAP, particularly concerning ILCs, remain unclear.
Purpose of the Study:
- To investigate the protective effects of the QXHY formula on intestinal injury in a mouse model of SAP.
- To elucidate the underlying mechanisms of QXHY action, focusing on the role of ILC3s.
Main Methods:
- A mouse model of SAP was induced using sodium taurocholate infusion.
- QXHY was administered orally to assess its impact on pancreatic and intestinal injury markers.
- Flow cytometry and qRT-PCR were employed to analyze ILC3 populations and their associated cytokine expression (IL-22, IL-17).
Main Results:
- QXHY treatment significantly reduced pancreatic injury markers (amylase, myeloperoxidase) and improved histopathology.
- QXHY mitigated intestinal damage, enhanced tight junction integrity, and decreased proinflammatory cytokines.
- QXHY therapy restored the number of RORγt+-ILC3s and upregulated IL-22 and IL-17 mRNA expression in SAP mice.
Conclusions:
- QXHY demonstrates a therapeutic potential in mitigating SAP-associated intestinal damage.
- The mechanism involves enhancing ILC3 cell activity, which helps regulate tissue injury and maintain homeostasis.
- QXHY presents a promising, cost-effective therapeutic option for SAP-related intestinal complications.
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