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Related Concept Videos

Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

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Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
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Acute Pancreatitis I: Introduction01:27

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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
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Chronic Pancreatitis II: Collaborative Care01:29

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Related Experiment Video

Updated: Jan 7, 2026

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
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Modified Marshall Score: An Underutilised Prognostication Tool for Acute Pancreatitis.

Charles Her Yi Ling1, Richard Bond1, Simon East1

  • 1General Surgery, York and Scarborough Teaching Hospitals NHS Foundation Trust, Scarborough, GBR.

Cureus
|December 8, 2025
PubMed
Summary

The Modified Marshall (MM) score for acute pancreatitis is underutilized in UK clinical practice. Simplifying the MM score improved its use, showing its value in identifying patients unlikely to need intensive care.

Keywords:
acute pancreatitisglasgow-imrie scoremodified marshall scoreorgan dysfunctionorgan failurerisk stratification

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Area of Science:

  • Gastroenterology and Hepatology
  • Surgical Critical Care

Background:

  • Acute pancreatitis (AP) is a significant cause of mortality, with organ failure complicating 20% of cases.
  • Early risk stratification is crucial for managing AP and preventing systemic injury.
  • The Modified Marshall (MM) score is a standard tool for assessing organ dysfunction in AP.

Purpose of the Study:

  • To evaluate the utilization of the MM score in acute pancreatitis patients.
  • To identify reasons for its underutilization in clinical practice.
  • To assess the MM score's effectiveness in risk stratification and predicting patient outcomes.

Main Methods:

  • Retrospective review of 127 AP patients over two years.
  • Analysis of electronic records, discharge letters, and handover sheets.
  • Questionnaire survey of clinicians regarding MM score underutilization.
  • Retrospective risk stratification using MM score, Glasgow-Imrie score, and CT severity index.

Main Results:

  • Only 18.9% of patients had an MM score documented.
  • Key underutilization reasons included unfamiliarity, complexity, and workload.
  • A simplified MM score and guidance improved utilization (7/10 patients).
  • Low MM scores (<2) accurately predicted no need for ITU or surgery (95.8% of patients).

Conclusions:

  • The Modified Marshall score is underutilized in current clinical practice.
  • Despite underutilization, the MM score is a reliable tool for risk stratification.
  • The MM score has a high negative predictive value, aiding trainees in identifying patients not requiring intensive care.