Elevated Transaminases Revealing Celiac Disease in a Patient With Normal Gastrointestinal Symptoms in a Tertiary...

Celiac disease (CD) is a lasting immune disease, most commonly with gastrointestinal symptoms; nonetheless, atypical symptoms of non-digestive tracts have now increasingly become common. We report the case of a 28-year-old woman with a history of constantly increased transaminases and no gastrointestinal symptoms. An extensive hepatic etiology testing was of no note. CD was diagnosed through the presence of positive anti-tissue transglutaminase IgA and duodenal biopsy. There was a great improvement, including liver enzyme normalization, in three months of a gluten-free diet. This case showed the necessity to consider CD as part of the diagnostic process of unexplained hypertransaminasemia despite the lack of gastrointestinal symptoms. Preventive measures of hepatic progression to widespread involvement and an increase in long-term prognosis can be achieved through dietary intervention and early diagnosis.