Remnant Cholesterol as a Superior Marker Over LDL-C for Hyperuricemia: A Cross-Sectional Study in Northwest China
Xixuan Lu1, Haiyan Liang1, Xiaoli Zhou1
1Department of Endocrinology, Cardiovascular and Cerebrovascular Disease Hospital, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, People's Republic of China.
Purpose:
Hyperuricemia is a precursor to gout and is linked to various metabolic disorders. This study investigated the associations of hyperuricemia with concordant/discordant lipid phenotypes based on low-density lipoprotein cholesterol (LDL-C) and remnant cholesterol (RC).
Methods:
We analyzed 8,971 participants from a cluster-stratified random sample across six provinces in Northwest China. They were categorized into four groups by LDL-C and RC levels: NRC+NLDL, NRC+HLDL, HRC+NLDL, and HRC+HLDL. Multivariable logistic regression was used to assess the odds of hyperuricemia across these groups.
Results:
Participants in Group NRC+HLDL, Group HRC+NLDL, and Group HRC+HLDL exhibited an increased risk for hyperuricemia by 37%, 96%, and 120%, respectively (OR: 1.37, 95% CI: 1.13-1.66 for NRC+HLDL; OR: 1.96, 95% CI: 1.57-2.45 for HRC+NLDL; OR: 2.20, 95% CI: 1.82-2.65 for HRC+HLDL), relative to Group NRC+NLDL. Subgroup analyses highlighted significant interaction effects based on gender and hypertriglyceridemia, with a more pronounced association observed in female participants. Sensitivity analyses revealed Group HRC+NLDL was most closely related to HUA when stricter LDL-C cut-offs were applied. Body mass index (BMI) and waist circumference (WC) mediated 20.27% and 6.67% of this association, respectively.
Conclusion:
RC demonstrated a stronger association with hyperuricemia than LDL-C, partially mediated by BMI and WC. Women exhibited greater susceptibility to RC-related hyperuricemia.
