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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

Updated: Jan 9, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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SCOPING: A Multidisciplinary Treatment Protocol for Neovascular Glaucoma with Completely Open or Partially Open

Nikita Mokhashi1, Jacob Kanter2, Rahul Komati3

  • 1Department of Ophthalmology and Visual Science, University of Chicago, Chicago, IL, USA.

Clinical Ophthalmology (Auckland, N.Z.)
|December 8, 2025
PubMed
Summary

The SCOPING protocol effectively treats neovascular glaucoma (NVG) by suppressing neovascularization and controlling intraocular pressure. This approach helps salvage the conventional outflow pathway in patients with open angles, reducing the need for surgery in some cases.

Keywords:
anti-vascular endothelial growth factormicro invasive glaucoma surgeriesneovascular glaucomapan-retinal photocoagulation

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Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Neovascularization Studies

Background:

  • Neovascular glaucoma (NVG) presents a significant challenge in ophthalmology.
  • Established treatments focus on reducing neovascular drive and intraocular pressure (IOP).
  • A standardized protocol for NVG management was lacking.

Purpose of the Study:

  • To evaluate the efficacy of the Salvaging the Conventional Outflow Pathway in Neovascular Glaucoma (SCOPING) protocol.
  • To suppress neovascular drive and control IOP in eyes with NVG.
  • To assess the potential for medical or surgical salvage of the anterior chamber angle.

Main Methods:

  • A multidisciplinary treatment protocol (SCOPING) was applied to 9 eyes with NVG.
  • Treatment involved serial monthly intravitreal bevacizumab injections.
  • Pan-retinal photocoagulation was interspersed with injections.

Main Results:

  • Five eyes with completely open angles achieved or maintained physiologic IOP without surgery.
  • Three of four eyes with partially open angles required subsequent IOP-lowering surgery.
  • No recurrence of anterior segment neovascularization was observed during the protocol.

Conclusions:

  • The SCOPING protocol may successfully salvage the conventional outflow pathway in NVG patients.
  • It offers a structured approach for managing NVG, particularly in eyes with open or partially open angles.
  • This protocol provides a valuable tool for glaucoma specialists treating neovascular glaucoma.