Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

343
The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
343
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

443
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
443
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

333
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
333
Hypertension IV: Drug Therapy and Lifestyle Modifications01:28

Hypertension IV: Drug Therapy and Lifestyle Modifications

578
Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
578
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

235
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
235
Management of Insomnia01:19

Management of Insomnia

507
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
507

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of exercise in cool versus hot conditions on pathways of gut permeability, systemic inflammation, and iron homeostasis in female athletes.

Physiological reports·2026
Same author

Examining Daily Associations of Nature Exposure, Body Appreciation, and Physical Activity Among Adolescents.

Health education & behavior : the official publication of the Society for Public Health Education·2026
Same author

Evidence of histamine release in response to both aerobic and resistance exercise: histamine metabolites as biomarkers.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same author

Delta-9-Tetrahydrocannabinol (THC) Before Bedtime: Feasibility and Mechanistic Pilot Study on Sleep and Cardiac Autonomic Activity.

Journal of sleep research·2026
Same author

Heat Therapy: Targeting Health, Disease, and Disability.

Comprehensive Physiology·2026
Same author

Unlocking the potential of circadian biology for cardiovascular health.

Physiological reviews·2026
Same journal

Protocol for academic-community collaboration in the Sweet Dreams study, a community-integrated study of time tradeoffs, sleep, and cardiometabolic health among minoritized women.

Sleep advances : a journal of the Sleep Research Society·2026
Same journal

What matters beyond model choice for wearable sleep staging? How personalization, evaluation choices, and easy-to-classify wake impact performance.

Sleep advances : a journal of the Sleep Research Society·2026
Same journal

Consumer sleep technologies: what we know and what comes next.

Sleep advances : a journal of the Sleep Research Society·2026
Same journal

Treating insomnia during pregnancy improves bedtime procrastination, rumination, anxiety, and positive affect: a randomized controlled trial of cognitive-behavioral and mindfulness-based therapies for prenatal insomnia.

Sleep advances : a journal of the Sleep Research Society·2026
Same journal

Hormonal contraceptives impair psychomotor vigilance task performance under sleep deprivation with stress induction.

Sleep advances : a journal of the Sleep Research Society·2026
Same journal

Automated sleep stage and event detection algorithms using quality-controlled polysomnography annotations.

Sleep advances : a journal of the Sleep Research Society·2026
See all related articles

Related Experiment Video

Updated: Jan 9, 2026

Multi-Modal Home Sleep Monitoring in Older Adults
07:40

Multi-Modal Home Sleep Monitoring in Older Adults

Published on: January 26, 2019

8.1K

Bedtime regularization as a potential adjunct therapy for hypertension: a proof-of-concept study.

Saurabh S Thosar1,2,3,4, Alakananda M Sreeramadas1, Megan Jones1

  • 1Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, United States.

Sleep Advances : a Journal of the Sleep Research Society
|December 8, 2025
PubMed
Summary
This summary is machine-generated.

Regularizing sleep schedules for two weeks lowered blood pressure (BP) in hypertensive individuals. This simple intervention reduced both daytime and nighttime BP, offering a potential new strategy for hypertension management.

Keywords:
bedtime regularizationblood pressurecircadian timinghypertension therapysleep regularizationsleep schedule

More Related Videos

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

647
Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

4.0K

Related Experiment Videos

Last Updated: Jan 9, 2026

Multi-Modal Home Sleep Monitoring in Older Adults
07:40

Multi-Modal Home Sleep Monitoring in Older Adults

Published on: January 26, 2019

8.1K
Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

647
Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

4.0K

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Public Health

Background:

  • Sleep irregularity is linked to increased blood pressure (BP).
  • The potential of sleep regularization to decrease BP remains unexplored.
  • Hypertension affects a significant portion of the global population, necessitating novel management strategies.

Purpose of the Study:

  • To investigate whether a 2-week sleep regularization intervention can reduce blood pressure (BP) in individuals with hypertension.
  • To test the hypothesis that improving sleep regularity leads to lower BP levels.

Main Methods:

  • Eleven participants with hypertension underwent a 2-week intervention focused on regularizing bedtime.
  • Ambulatory blood pressure (BP) and sleep patterns were monitored using actigraphy before and after the intervention.
  • Variability in bedtime and sleep onset was quantified using standard deviations.

Main Results:

  • The intervention significantly reduced bedtime and sleep onset variability.
  • A significant decrease in 24-hour systolic BP (-4±4 mmHg) and diastolic BP (-3±3 mmHg) was observed.
  • Nighttime systolic BP and diastolic BP also showed significant reductions, indicating improved nocturnal BP control.

Conclusions:

  • Two weeks of bedtime regularization effectively decreased 24-hour and nighttime BP in hypertensive individuals.
  • Sleep regularization presents a low-risk, adjunctive strategy for managing hypertension.
  • Further validation in larger randomized controlled trials is warranted to confirm these findings.