Research progress on hyperbaric oxygen therapy for refractory peptic ulcer disease.

Area of Science:

• Gastroenterology
• Hyperbaric Medicine

Background:

• Refractory peptic ulcer disease (RPUD) presents significant clinical challenges due to poor treatment response and high recurrence rates.
• Standard treatments, including proton pump inhibitors, have limitations, especially with drug-resistant *Helicobacter pylori* and NSAID co-administration.

Purpose of the Study:

• To provide a systematic overview of current research on hyperbaric oxygen therapy (HBOT) for treating RPUD.
• To highlight the emerging therapeutic potential of HBOT in managing refractory peptic ulcers.

Main Methods:

• Review of recent studies and emerging evidence on HBOT for refractory inflammatory bowel disease (IBD).
• Systematic assessment of HBOT's efficacy in treating refractory peptic ulcers.

Main Results:

• HBOT has demonstrated promising therapeutic outcomes in managing refractory inflammatory bowel disease.
• Emerging evidence indicates significant efficacy of HBOT in the treatment of refractory peptic ulcers.

Conclusions:

• Hyperbaric oxygen therapy is an emerging and effective treatment for refractory peptic ulcer disease.
• Further research into HBOT for RPUD is warranted to establish its role in clinical practice.