Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

734
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
734

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From topography to connectome: Towards an integrated understanding of the resting brain.

bioRxiv : the preprint server for biology·2026
Same author

PIK3CA mutant cervical cancer is selectively suppressed by PI3Kα inhibition (Alpelisib/BYL-719 and Inavolisib/GDC-0077) and cooperates with HPV directed T cell therapy.

Neoplasia (New York, N.Y.)·2026
Same author

Sex differences in the enjoyment of enrichment: affective bias testing confirms female rats prefer more playful and less vigorous tickling.

Biology letters·2026
Same author

HLA class I signal peptide variation predicts strength of NKG2A<sup>+</sup> NK cell response to missing-self and risk of human disease.

Nature immunology·2026
Same author

Respiratory function in Becker muscular dystrophy: a comprehensive longitudinal study.

Journal of neurology, neurosurgery, and psychiatry·2026
Same author

<i>STK11</i> mutations and deletions define a distinct subtype of cervical adenocarcinoma.

medRxiv : the preprint server for health sciences·2026

Related Experiment Video

Updated: Jan 9, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

54.4K

Pembrolizumab-Induced Secondary Cholangitis: A Case Report.

Nur Aisyah Muhd Opandi1, Aqeel Ahmed1, Emma Robinson1

  • 1Internal Medicine, Chesterfield Royal Hospital NHS Foundation Trust, Chesterfield, GBR.

Cureus
|December 8, 2025
PubMed
Summary

Immune checkpoint inhibitors (ICIs) can cause rare immune-related cholangitis, a serious bile duct inflammation. Early diagnosis and immunosuppressive treatment are crucial for managing this adverse event in cancer patients.

Area of Science:

  • Oncology
  • Immunology
  • Hepatology

Background:

  • Immune checkpoint inhibitors (ICIs) are vital cancer therapies but can cause immune-related adverse events (IrAEs).
Keywords:
acute cholangitisimmune check-point inhibitorimmunotherapyimmunotherapy-related adverse eventsnon-small cell lung carcinoma (nsclc)pembrolizumabpembrolizumab side effectprimary sclerosing cholangitis (psc)

More Related Videos

Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb
04:50

Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb

Published on: January 17, 2025

653
Robotic Taj Mahal Hepatectomy for Hilar Cholangiocarcinoma
09:19

Robotic Taj Mahal Hepatectomy for Hilar Cholangiocarcinoma

Published on: July 14, 2022

4.1K

Related Experiment Videos

Last Updated: Jan 9, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

54.4K
Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb
04:50

Complete Laparoscopic Radical Resection of Perihilar Cholangiocarcinoma Type IIIb

Published on: January 17, 2025

653
Robotic Taj Mahal Hepatectomy for Hilar Cholangiocarcinoma
09:19

Robotic Taj Mahal Hepatectomy for Hilar Cholangiocarcinoma

Published on: July 14, 2022

4.1K
  • While immune-related hepatitis is recognized, immune-related cholangitis (bile duct inflammation) is rarer and less understood.
  • Immune-related cholangitis can lead to severe outcomes, including liver failure and death.