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Pembrolizumab-Induced Secondary Cholangitis: A Case Report

Nur Aisyah Muhd Opandi1, Aqeel Ahmed1, Emma Robinson1

  • 1Internal Medicine, Chesterfield Royal Hospital NHS Foundation Trust, Chesterfield, GBR.

Cureus
|December 8, 2025
PubMed
Summary

Immune checkpoint inhibitors (ICIs) can cause rare immune-related cholangitis, a serious bile duct inflammation. Early diagnosis and immunosuppressive treatment are crucial for managing this adverse event in cancer patients.

Keywords:
acute cholangitisimmune check-point inhibitorimmunotherapyimmunotherapy-related adverse eventsnon-small cell lung carcinoma (nsclc)pembrolizumabpembrolizumab side effectprimary sclerosing cholangitis (psc)

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