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Updated: Jan 9, 2026

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
Sodium Hypophosphite Assisted Ruthenium Catalyzed Reductive Amination under Mild Conditions
Olesya Zvereva1,2, Fedor S Kliuev1,2, Natalia Lebedeva1
1A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, INEOS, Vavilova St. 28, Moscow 119334, Russia.
None:
We report a catalytic method for reductive amination using sodium hypophosphite as a cheap, bulk-grade available, and environmentally friendly reductant. The use of CpRu(PPh3)2Cl allowed the reaction to proceed under mild conditions, affording products in preparative yields. The method demonstrated great tolerance for a wide range of functional groups. A set of mechanistic trials resulted in one of the possible catalytic species, the Ru-hydride complex, being identified by NMR. A plausible mechanism of the process was proposed.
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