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Impact of Perforin 1 A91V germ line background in patients with aggressive B-NHL treated with R-CHOP

Onur Cetin1, Igor Age Kos1, Evi Regitz1

  • 1José Carreras Center for Immuno- and Gene Therapy and Department of Internal Medicine I, Saarland University Medical School, Homburg, Germany.

Blood Advances
|December 8, 2025
PubMed
Abstract

No abstract available in PubMed .

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Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
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The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...

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