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Updated: Jan 9, 2026

Wideband Optical Detector of Ultrasound for Medical Imaging Applications
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Artificial-intelligence-based design optimization of low-noise transimpedance amplifiers for optical detection.

Patricia M E Vázquez1, Ligia Ciocci Brazzano1,2, Francisco E Veiras1

  • 1Universidad de Buenos Aires, Facultad de Ingeniería, Departamento de Física, GLOmAe, Ciudad Autónoma de Buenos Aires, Argentina.

The Review of Scientific Instruments
|December 8, 2025
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Summary

Artificial intelligence (AI) optimizes transimpedance amplifiers for optical detection using a Genetic Algorithm (GA). This AI-driven design significantly outperforms traditional Monte Carlo methods in efficiency and accuracy for photodetector development.

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Area of Science:

  • Electrical Engineering
  • Optical Instrumentation
  • Artificial Intelligence

Background:

  • Transimpedance amplifiers are crucial for electro-optical systems, particularly in optical ultrasound detection.
  • Optimizing these amplifiers is key to improving system performance and reducing noise.

Purpose of the Study:

  • To present an AI-based design optimization of transimpedance amplifiers for optical detection using a Genetic Algorithm (GA).
  • To explore the influence of GA parameters on optimization performance.
  • To compare AI-based optimization with Monte Carlo (MC) methods and experimental validation.

Main Methods:

  • Utilized a Genetic Algorithm (GA) for the design optimization of photodetectors.
  • Investigated the impact of GA parameters such as population size, generations, and mutation rate.
  • Compared GA optimization results against Monte Carlo (MC) optimization and systematic search benchmarks.
  • Experimentally validated the AI-based optimized photodetector.

Main Results:

  • AI-based optimization with specific GA parameters (population size 1000, 10 generations, 5% mutation) required only 104 evaluations, achieving results within 0.12% of the maximum merit.
  • MC optimization needed significantly more evaluations (3.4 × 10^5) for comparable statistical results.
  • Demonstrated power-law scaling of performance with initial population size for both GA (exponent 1.2) and MC (exponent 0.88).
  • Experimental validation confirmed the AI-based optimization's accuracy.

Conclusions:

  • AI-based design optimization using GA is a highly efficient and promising method for developing low-noise transimpedance amplifiers.
  • This approach offers superior performance and reduced computational cost compared to traditional methods like MC optimization.
  • The validated AI method is applicable to various photodetector designs, including those for ultrasound detection, general-purpose use, and quantum processing research.