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Updated: Jan 9, 2026

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
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The hidden regulators: Non-coding RNAs in KMT2A-rearranged acute lymphoblastic leukemia

Maria Augusta Poersch1, Ana Carolina Rodrigues1, Priscila Elias Ferreira Stricker1

  • 1Genetics Post-Graduation Program, Genetics Department, Federal University of Parana, Curitiba, Parana, Brazil.

International Journal of Cancer
|December 8, 2025
PubMed
Summary

Non-coding RNAs (ncRNAs) play a critical role in KMT2A-rearranged infant acute lymphoblastic leukemia (ALL). These molecules influence gene expression and epigenetic regulation, offering potential as biomarkers and therapeutic targets.

Keywords:
KMT2A rearrangementacute lymphoblastic leukemiamixed lineage leukemianon‐coding RNAs

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