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  3. Gutmsnp: A Comprehensive Database For Human Gut Microbial Single-nucleotide Polymorphisms.
  1. Home
  3. Gutmsnp: A Comprehensive Database For Human Gut Microbial Single-nucleotide Polymorphisms.

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gutMSNP: a comprehensive database for human gut microbial single-nucleotide polymorphisms.

Kai Qian1, Meiyu Du1, Senwei Tan1

  • 1College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang150081, China.

Nucleic Acids Research
|December 8, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

The gut microbiome harbors millions of single-nucleotide polymorphisms (SNPs) crucial for microbial function and host health. The gutMSNP database offers a comprehensive resource for exploring these SNPs and their impact on gut microbial genomes.

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Area of Science:

  • Microbiology
  • Genomics
  • Bioinformatics

Background:

  • Single-nucleotide polymorphisms (SNPs) in gut microbial genomes significantly influence microbial pathogenicity and host health.
  • Understanding these SNPs is vital for elucidating microbial functions and mechanisms in microbiota-driven disorders.
  • A large-scale, standardized SNP repository is essential for comprehensive analysis.

Purpose of the Study:

  • To introduce gutMSNP, a user-friendly database resource for human gut microbiome SNPs.
  • To provide a systematic and comprehensive collection of SNPs, their annotations, and associated data.
  • To offer integrated tools for SNP analysis within the gut microbiome.

Main Methods:

  • Identification and categorization of over 164 million SNPs across human gut microbial genomes.
  • Inclusion of species-level and gene-level microbial records with phenotype-specific SNP distribution patterns.
  • Integration of 8146 reference genomes and an online SNP capturing tool.

    • Main Results:

    • gutMSNP contains 164,015,783 SNPs across gut microbial genomes at three confidence levels.
    • The database includes 364 species-level and 8251 gene-level records detailing phenotype-specific SNP patterns.
    • 8146 reference genomes are available, alongside tools for SNP searching, annotation, and analysis.

    Conclusions:

    • gutMSNP serves as a fundamental resource for SNP-based research in the human gut microbiome.
    • The database facilitates detailed investigations into microbial functions and host-microbe interactions.
    • Its comprehensive dataset and analytical tools empower researchers in microbiome studies.