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Renin production in Chagas' disease.

A Da Costa e Silva, R H Albuquerque, P A Cardoso

    Biomedicine / [Publiee Pour L'A.A.I.C.I.G.]
    |November 1, 1977
    PubMed
    Summary

    Chagas' disease (Trypanosomiasis cruzi) affects kidney innervation, altering plasma renin activity. Early stages show high renin production, while later digestive forms exhibit low renin levels, indicating disease progression.

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    Area of Science:

    • Cardiovascular Physiology
    • Nephrology
    • Infectious Diseases

    Background:

    • Chagas' disease, caused by Trypanosoma cruzi, can impact autonomic nervous system function.
    • Renin-angiotensin-aldosterone system (RAAS) plays a crucial role in blood pressure regulation and kidney function.
    • Autonomic dysfunction is a known complication of Chagas' disease, but its specific effects on renal innervation are not fully elucidated.

    Purpose of the Study:

    • To investigate plasma renin activity in patients with Chagas' disease.
    • To assess the relationship between autonomic nervous system defects and renin production in Chagas' disease.
    • To correlate renin activity patterns with different clinical forms of Chagas' disease.

    Main Methods:

    • Plasma renin activity was measured in peripheral venous blood of six controls and ten Chagas' disease patients.
    • Measurements were taken after a 12-hour supine rest and at multiple time points (5, 15, 30, 60, 240 minutes) after assuming an upright position.
    • The study aimed to identify evidence of postganglionic autonomic defects in sympathetic efferent kidney innervation.

    Main Results:

    • A defect in sympathetic efferent kidney innervation was observed in Chagas' disease patients.
    • Two distinct patterns of renin production correlated with clinical forms: high renin in asymptomatic/intermediate stages.
    • Low renin production was associated with the digestive form of Chagas' disease.

    Conclusions:

    • Autonomic dysfunction in Chagas' disease significantly impacts renal sympathetic innervation.
    • Plasma renin activity serves as a potential biomarker for disease staging and progression.
    • The findings suggest a two-stage alteration in renin production linked to the clinical evolution of Chagas' disease.

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