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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

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This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
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Related Experiment Video

Updated: Jan 7, 2026

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
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Rethinking Colorectal Cancer Screening: Culturally Tailored Navigation for Mailed FIT Kits in 45- to 49-Year-Olds.

David M Callender1, Lindsay Hauser2, Cynthia Yoshida3

  • 1Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA. dc7zm@uvahealth.org.

Journal of General Internal Medicine
|December 8, 2025
PubMed
Summary

A mailed fecal immunochemical test (FIT) program with culturally tailored navigation significantly increased colorectal cancer screening rates in adults aged 45-49, particularly among Hispanic patients, reducing disparities.

Keywords:
Colorectal cancer (CRC) screeningFecal immunochemical test (FIT)Patient navigationUnderserved populations

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Area of Science:

  • Public Health
  • Preventive Medicine
  • Health Equity

Background:

  • Rising colorectal cancer (CRC) incidence in younger adults necessitates screening initiation at age 45.
  • Screening rates among 45- to 49-year-olds remain suboptimal.
  • Mailed fecal immunochemical test (FIT) programs show potential for increasing CRC screening uptake.

Purpose of the Study:

  • To assess the effectiveness of a mailed FIT program incorporating culturally tailored navigation.
  • To improve CRC screening rates in adults aged 45-49 within a safety-net primary care setting.

Main Methods:

  • A quality improvement initiative targeted eligible patients aged 45-49 lacking CRC screening.
  • Culturally tailored, multilingual invitations and FIT kits were mailed, utilizing the health belief model.
  • Multi-modal navigation included patient education, bilingual calls, and reminder letters.

Main Results:

  • 143 of 589 (24%) patients returned completed FIT kits.
  • Hispanic patients demonstrated higher FIT return rates (29%) compared to non-Hispanic patients (21%).
  • Navigation outreach led to a 16% return rate for outstanding FITs, with 8% testing positive and 73% receiving follow-up colonoscopy.

Conclusions:

  • Culturally tailored mailed FIT interventions with navigation effectively increase CRC screening in newly eligible younger adults.
  • This approach shows promise in reducing screening disparities, especially for Hispanic populations.
  • Broader implementation of such navigation services can advance health equity in primary care.